Prion research
We dissect prion replication, spread, and toxicity using unbiased CRISPR genomic screens, advanced cell models, and organotypic brain cultures.
Read the chapter →Parkinson’s disease
We identify genetic modifiers of α-synuclein pathology using high-throughput screening approaches in human cellular models of disease.
Read the chapter →Cloning human antibodies
We map autoantibodies at scale and validate antigen-specific responses in large cohorts to discover protective human antibodies that can be used therapeutically.
Read the chapter →Unbiased genetic screens
We have constructed genome-wide, unbiased CRISPR arrayed libraries to interrogate biochemical, morphological, and cell-nonautonomous phenotypes that are inaccessible to pooled approaches.
Read the chapter →