ISAB unites molecular biology, neuroscience, and translational medicine to discover actionable targets against prion diseases, Parkinson’s disease, and related proteinopathies.
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We dissect prion replication, spread, and toxicity using unbiased CRISPR genomic screens, advanced cell models, and organotypic brain cultures.
Read the chapter →We identify genetic modifiers of β-glucocerebrosidase (GCase) activity and test how they shape α-synuclein pathology in human iPSC-derived neurons.
Read the chapter →We map autoantibodies at scale (REAP) and validate antigen-specific responses in large cohorts (TRABI) to discover protective human antibodies.
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